Scientific aspects of the therapeutic use of andrographis paniculata kalmegh. Phytochemical study was made on the different plant extract. Phytochemical analysis of andrographis paniculata extract and its antimicrobial activity article pdf available in world journal of microbiology and biotechnology 261. This plant is a richest source of bioactive constituents used in india to treat diseases, so far. Andrographis paniculata nees is a slender upright annual varying in height from 30 to 100 cm 1 to 3 feet, with a square stem and lanceolate leaves. Biological activities of kalmegh andrographis paniculata nees. Material and methods with 250 and 500 mgkg of the leaf extract respectively, plant material fresh and healthy leaves of a. If you continue browsing the site, you agree to the use of cookies on this website.
Andrographis paniculata is one of the highly used potential medicinal plants in the world. It is colorless, crystalline, bitter in taste and known as diterpene lactone. The aerial parts contains alkanes, ketones, and aledehydes. A highpressure liquid chromatography chemical fingerprint for the extract of a. Andrographis paniculata, commonly known as creat or green chireta, is an annual herbaceous plant in the family acanthaceae, native to india and sri lanka. Andrographis paniculata has been used for centuries as a medicinal herb due to its unique ability to treat various ailments like jaundice, asthma, hypoglycemia, leprosy, gonorrhea, scabies, skin eruptions, hypertension, upper respiratory infections, fever, herpes and other chronic diseases 1,2.
Chemical composition of andrographis paniculata burm. Biological activities of kalmegh andrographis paniculata. Pdf phytochemical analysis of andrographis paniculata extract. Uses, benefits, cures, side effects, nutrients in andrographis paniculata. Andrographis is promoted in supplemental form for cancer prevention, cancer treatment, and to counter chemotherapy toxicity in.
Chemical constituents of andrographis paniculata impact factor. The stems and leaves of the plant are used to extract the active phytochemicals. It is also used in folk medicine to treat snakebites. In animal and in vitro experiments using human cancer cell lines to investigate the potential anticancer effects of a. Phytochemical studies of leaf of the herbs, andrographis paniculata and andrographis lineate. Chemical constituents therapeutically important active principle of kalmegh found in aerial parts is andrographolide c 20 h30 o5, mp 230239. Nees family, acanthaceae grows widely in many asian countries, such as china, india, thailand and sri lanka and has a long history of therapeutic usage in indian and oriental medicine. Flavonoids mainly exist in the root, but also have been isolated from the leaves. Andrographolide, a major bioactive chemical constituent of the plant, has shown anticancer potential in various.
A phytochemical investigation on andrographis paniculata. Chemical investigation of the dichloromethane extracts of andrographis paniculata burm. It is fairly effective when taken for three to five days after the symptoms first appear. Pharmacological aspects of andrographis paniculata on. Presence of phenolic compounds, flavonoids, alkaloids saponins and tannins and absence of. Pdf biological and pharmacological activities of andrographis.
List of various diseases cured by andrographis paniculata. In the chinese medical tradition, the plant has been used to treat everything from gastrointestinal complaints to throat infections. Antidengue viral compounds from andrographis paniculata. Experimental and clinical pharmacology of andrographis. The structure was elucidated on the basis of spectroscopic analysis like 1 h, c, c dept, 1 h1 h cosy. Review article scientific aspects of the therapeutic use of. This plant is traditionally used for the treatment of common cold, diarrhoea, fever due to several infective cause, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. Fifteen compounds, including flavonoids and diterpenoid lactones. Chemical constituents isolated from andrographis paniculata nopr. For centuries, the ayurvedic practitioners of india have used the roots and leaves of the herb andrographis paniculata to treat ailments ranging from poor digestion to hepatitis.
Usda, ars, germplasm resources information network. Dunal, in principles and practice of phytotherapy second edition, 20botany. Though it is not proved people believe that the plant is a repellent for snakes. A systematic phytochemical investigation of andrographis paniculata led to the isolation of a bicyclic diterpenoid lactone andrographolide and a well known plant sterol. Pdf chemical composition of andrographis paniculata. Pdf phytochemical analysis of andrographis paniculata. Medicinal and pharmacological activities of andrographis. Nees article pdf available in international journal of pharmacognosy and phytochemical research 88 august 2016 with 2,540 reads. Andrographis paniculata, is a herbaceous plant belonging to the family acanthaceae.
Chemical constituents of andrographis paniculata burm. Flavonoids and andrographolides from andrographis paniculata. Efficacy of an andrographis paniculata composition for the. Moghaddamahmadi, in nutrition and lifestyle in neurological autoimmune diseases, 2017. Lets check the bioefficacy of andrographis paniculata. Pdf chemical constituents isolated from andrographis. Apr 27, 2014 andrographis paniculata wall family acanthaceae is one of the most popular medicinal plants used traditionally for the treatment of array of diseases such as cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria for centuries in asia, america and africa. To investigate the chemical constituents of the roots of andrographis paniculata, 28 compounds were. Medicinal and pharmacological properties of andrographis. Department of agriculture agricultural research service. Chemical constituents medicinal uses uses described in folk medicine, not supported by experimental or clinical data biological and pharmacological activity supported by experimental data clinical studies safety information.
Andrographis paniculata uses, benefits and side effects. Different active constituents have been identified, including andrographolide, deoxyandrographolide and other diterpenes. The structures of these compounds have been established on the basis of spectral data analysis. F nees, generally known as king of bitters, is an herbaceous plant in the family acanthaceae. The primary active constituent of andrographis paniculata is the andrographolide chen and liang, 1982. Andrographis paniculata herb uses, benefits, cures, side. Andrographis paniculata supplement health benefits. Antidiabetic and antioxidant potential of andrographis. Andrographis paniculata, isolation, method development. In recent years, a medicinal plant, andrographis paniculata, and its major active phytochemicals have been extensively studied for several pharmacological activities. Phytochemical analysis of andrographis paniculata extract. Senthilkumar abstract to investigate the protective effect of the leaf extract of andrographis paniculata ap.
Pdf the present study describes the phytochemical profile and antimicrobial. Andrographis memorial sloan kettering cancer center. Dehydroandrographolide inhibited hiv1 and hiv1 ucd123 infection of h9 cells at 1. Review article scientific aspects of the therapeutic use. Andrographis paniculata is an annual shrub belonging to the acanthaceae family. How andrographis paniculata is effective for various diseases is listed in repertory format. Hcl, respectively, were compared for their antimicrobial activity and further subjected to gcms analysis to find out the nature of the compounds. Its major constituents are diterpenoids, flavonoids and polyphenols. Andrographis paniculata is used to treat the common cold.
Antidengue viral compounds from andrographis paniculata by. Hepatoprotective potential of andrographis paniculata aqueous leaf extract on ethanol induced liver toxicity in albino rats a. Isolation and identification of bioactive compounds in andrographis. Andrographis paniculata contains diterpenes, lactones, and flavonoids. Andrographis paniculata an overview sciencedirect topics.
Nees article pdf available in research journal of pharmaceutical, biological and chemical sciences 76 november 2016 with 970 reads. Andrographis paniculata is a traditional medicinal plant used in madhya pradesh, it is commonly known as kalmegh. Andrographolide, a major bioactive chemical constituent of the plant, has shown anticancer potential in various investigations. Pdf chemical constituents of andrographis paniculata. Andrographis paniculata, commonly known as king of bitters, is an herb traditionally used in ayurveda and traditional chinese medicine. The dichloromethane extracts of the leaves of andrographis paniculata led to the isolation of neoandrographolide 1, 1,5dimethyl1,5cyclooctadiene 2 and 2hydroxyethyl benzoate 3, and squalene 4 from the leaves, while the stems yielded 1 and. Chemical constituents from roots of andrographis paniculata. In the chinese medical tradition, the plant has been used to treat everything from. Harnessing the medicinal properties of andrographis paniculata for. Particularly, andrographis paniculata nees is used for several applications such as an antidote for snakebite and poisonous stings of some insects, and to treat dyspepsia, influenza, dysentry, malaria and respiratory infections kirtikar and.
Evaluation of phytochemical and antimicrobial activity of. Nees acanthaceae is a medicinal plant used in many countries. Names of andrographis paniculata in various languages of the world are also given. In china, india, thailand, and malaysia, this plant has been widely used for treating sore throat, flu, and upper respiratory tract infections. View andrographis paniculata research papers on academia. It is colorless bitter in taste and crystalline and known as diterpene. It has been used for centuries in traditional folk medicine in india, china, thailand, and other asian countries. Andrographis paniculata wall family acanthaceae is one of the most popular medicinal plants used traditionally for the treatment of array of diseases such as cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria for centuries in asia, america and africa continents. Andrographis paniculata, the key facts for therapeutic use. Aug 14, 2019 andrographis paniculata, commonly known as king of bitters, is an herb traditionally used in ayurveda and traditional chinese medicine. Nees led to the isolation of andrographolide 1, 14. It is often used in combination with other herbs in traditional medicine to treat infectious diseases and associated fevers. Qualitative and quantitative analysis of andrographis paniculata by.
Andrographolide is a bicyclic diterpenoid lactone derived from the extracts of andrographis paniculata, a plant originating from southeast asian countries that has been used as an official medicinal herb in china. Andrographis paniculata andrographis is an ancient medicinal herb with a long historical record. Andrographis paniculata, the key facts for therapeutic use stephen behr, ph. Harnessing the medicinal properties of andrographis. The major constituents in andrographis are diterpene lactones known as. The plant profiler provides detailed information and bioactive compounds for numerous different plant species. The leaves contain the maximum active principle content while in the stem it is in lesser amount.
Assessment report on andrographis paniculata nees, folium. Phytochemical analysis of andrographis paniculata extract and. Tan yee kuan the increasing of antibiotic resistance bacteria and synthetic drugs has urged the search of new antibacterial and antioxidant agents from medicinal plants. As aboriginal sources of medications, medicinal plants are used from the ancient times. Andrographis paniculata supplement health benefits, dosage. A number of evidence has been accumulated to demonstrate promising potential of medicinal plants used in various traditional, complementary, and alternative systems. Andrographolide is one of the major diterpene lactone found in the pant. It is a major active constituent of and accepted by union health ministry. Andrographis is promoted in supplemental form for cancer prevention, cancer treatment, and to counter chemotherapy toxicity in humans.
Chemical constituents isolated from andrographis paniculata. Pdf chemical composition of andrographis paniculata burm. Kalmegh contains bitter principles andrographolide, a bicyclic diterpenoid lactone and kalmeghin upto 2. Andrographis paniculata in the germplasm resources information network grin, u. A methanol extract of the leaves suppressed syncytia formation in cocultures of uninfected and hiv1. Andrographolide and 14 deoxy 11 oxoandrographolide are main active compounds of thea. Bicyclic diterpenoid and phytosterol constituents from.
It grows to a height of 1 metre with branches that are sharply quadrangular, often narrowly winged towards the apical region. Chemical structures of some major compounds present in andrographis paniculata chemistry therapeutically active constituent of kalmegh found in aerial parts. The present study describes the phytochemical profile and antimicrobial activity of andrographis paniculata. Article pdf available in international journal of research in ayurveda and pharmacy 36. Phytochemicals screening and antibacterial activity of andrographis paniculata. Aug 11, 2009 the present study describes the phytochemical profile and antimicrobial activity of andrographis paniculata. Andrographis andrographis paniculata plant profiler.
899 438 786 1307 206 794 1297 1316 1475 79 180 1497 211 1030 1206 1318 707 1568 282 1515 1254 136 124 1172 1411 172 438 520 1338 42 523 1459 358 995 409 357 833 698 1196